EyePoint Pharmaceuticals Announces Completion of Enrollment of Phase 1 DAVIO Clinical Trial of EYP-1901 for the Potential Treatment of Wet AMD
“We are pleased to report the completion of enrollment of all three dose cohorts in our ongoing Phase 1 trial of EYP-1901,” said
The ongoing Phase 1 DAVIO trial for EYP-1901 is an open-label twelve-month dose escalation trial examining wet AMD patients who were responsive to previous anti-VEGF therapies. The primary endpoint of the trial is safety and key secondary endpoints are changes in best-corrected visual acuity (BCVA) and central subfield thickness. EYP-1901 is delivered via a single intravitreal injection in the physician's office. The Company anticipates that six-month interim data will include initial safety and efficacy evaluations. More information on the Phase 1 DAVIO trial may be found at www.clinicaltrials.gov (NCT04747197).
EYP-1901 is a potential twice-yearly sustained delivery intravitreal anti-VEGF treatment for wet age-related macular degeneration, currently being studied in a Phase 1 clinical trial. EYP-1901 combines a bioerodible formulation of EyePoint’s proprietary Durasert® drug release technology and vorolanib, a tyrosine kinase inhibitor. Durasert provides sustained, controlled and consistent zero order kinetics drug delivery, and vorolanib demonstrated clear efficacy signals in two prior human trials in wet AMD as an orally delivered therapy with no significant ocular adverse events. Preclinical studies of EYP-1901 have shown anti-VEGF activity in disease models of ocular neovascularization and no serious safety issues were observed. EYP-1901 is also anticipated to be studied for the potential treatment of diabetic retinopathy and retinal vein occlusion in future clinical trials.
About Wet Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is a condition that affects the part of the eye that provides sharp, central vision needed for normal living activities. Wet AMD is an advanced form of the disease that can cause rapid and severe vision loss. The hallmark of wet AMD is the development of new, abnormal blood vessels in center of the retina resulting in fluid accumulation, bleeding and/or fibrosis. Wet AMD is the leading cause of vision loss in people over the age of 60,and the disease will affect even more people as the global population ages.
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Source: EyePoint Pharmaceuticals, Inc.